Cancer Cells Mimic White Blood Cells to Metastasize: NHRI Deciphers Target-Driving Protein

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A National Health Research Institutes (NHRI) team discovered that cancer cells mimic white blood cells, moving like amoebas to enter and exit blood vessels and metastasize to distant tissues. This process is driven by the overexpression of the transmembrane protein MYADM, which is significantly correlated with high recurrence rates and low patient survival in various cancers. The team has developed preliminary monoclonal antibodies and proteolysis-targeting chimeras (PROTACs), and confirmed that blocking MYADM significantly reduces cancer cell dissemination, offering a new potential target for cancer therapy.