Snow Brand Seed Co., Ltd. (Head Office: Minato-ku, Tokyo; President: Masaya Matsunaga), part of the Snow Brand Milk Products Group, is pleased to announce its report on the physiological functions of "polyamines," a breast milk component expected to be related to the reduction of food allergy risk, at the 25th Neonatal Nutrition Forum held from June 20-21, 2026. The "Neonatal Nutrition Forum" is an academic conference attended by doctors and medical professionals involved in neonatal medicine nationwide, aiming to disseminate and share the latest knowledge on neonatal nutrition, including for high-risk newborns. Our company typically reports on the results of national breast milk surveys in corporate sessions. ◆Presentation Content Polyamines are a general term for substances such as putrescine, spermidine, and spermine. They are widely present in living organisms and are known to be involved in cell differentiation, proliferation, and immune regulation. They are also found in breast milk and are suggested to be involved in the maturation of the developing digestive tract in infancy, potentially suppressing the invasion of foreign substances by forming the intestinal barrier function. Their involvement in immune function has also been reported, suggesting they may contribute to balancing immunity while suppressing excessive inflammatory responses. Furthermore, the 3rd National Breast Milk Survey, conducted jointly with Snow Brand Milk Products Co., Ltd. since 2015, has suggested a possible link between higher polyamine concentrations in breast milk and a lower risk of developing food allergies in infants. This presentation introduced the findings on the physiological functions of polyamines in breast milk, combined with epidemiological findings from the 3rd National Breast Milk Survey, and explained their potential role in the development of food allergies (Figure 1). Figure 1: Assumed mechanism for reducing the risk of food allergy development by breast milk compon